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Abstract #0375

Inhomogeneous Magnetization Transfer (ihMT) imaging of the human brain at 7T

Olivier M. Girard1,2, Lucas Soustelle1,2, Thomas Troalen3, Andreea Hertanu1,2, Arash Forodighasemabadi1,2,4,5, Maxime Guye1,2, Jean-Philippe Ranjeva1,2, Gopal Varma6, David C. Alsop6, and Guillaume Duhamel1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Siemens Healthcare SAS, Saint-Denis, France, 4Aix-Marseille Univ, Université Gustave Eiffel, LBA, Marseille, France, 5iLab-Spine International Associated Laboratory, Marseille - Montreal, France, 6Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States


Inhomogeneous Magnetization Transfer (ihMT) MRI has raised interest for myelin imaging. Applications at ultra-high field are appealing for SNR considerations but are challenged by the reduction of available RF power due to regulatory SAR constraints and the need to account for inhomogeneities of the RF excitation field (B1+). In the current study we present experimental data acquired at 3T which validate two B1+-bias removal strategies. Then we further evaluate them at 7T and show preliminary results towards a robust ihMT protocol free from B1+ bias.

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