Abstract #0375

Inhomogeneous Magnetization Transfer (ihMT) imaging of the human brain at 7T

Olivier M. Girard^1,2, Lucas Soustelle^1,2, Thomas Troalen³, Andreea Hertanu^1,2, Arash Forodighasemabadi^1,2,4,5, Maxime Guye^1,2, Jean-Philippe Ranjeva^1,2, Gopal Varma⁶, David C. Alsop⁶, and Guillaume Duhamel^1,2

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Siemens Healthcare SAS, Saint-Denis, France, ⁴Aix-Marseille Univ, Université Gustave Eiffel, LBA, Marseille, France, ⁵iLab-Spine International Associated Laboratory, Marseille - Montreal, France, ⁶Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Synopsis

Inhomogeneous Magnetization Transfer (ihMT) MRI has raised interest for myelin imaging. Applications at ultra-high field are appealing for SNR considerations but are challenged by the reduction of available RF power due to regulatory SAR constraints and the need to account for inhomogeneities of the RF excitation field (B₁⁺). In the current study we present experimental data acquired at 3T which validate two B₁⁺-bias removal strategies. Then we further evaluate them at 7T and show preliminary results towards a robust ihMT protocol free from B₁⁺ bias.

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