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Abstract #0376

Feasibility of magnetization transfer measurement in distinct white matter connections

Pietro Bontempi1,2, Ilana R. Leppert3, Simona Schiavi1,4, Jennifer S. W. Campbell3, Mark Nelson3,5, Bruce G. Pike6, Christine L. Tardif3,5,7, and Alessandro Daducci1
1Department of Computer Science, University of Verona, Verona, Italy, 2Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy, 3McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 4Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genova, Italy, 5Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 6Hotchkiss Brain Institute and Departments of Radiology and Clinical Neuroscience, University of Calgary, Calgary, AB, Canada, 7Department of Biomedical Engineering, McGill University, Montreal, QC, Canada


Magnetization Transfer (MT) imaging is a MR technique that sensitizes image contrast to protons bound to macromolecules such as protein and lipids. Using an innovative sequence that combines MT and diffusion- imaging, and Convex Optimization Modeling for Microstructure Informed Tractography (COMMIT), a method that allows estimation of bundle tissue properties, we investigate bundle specific MT ratio (MTR) values.

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