Compartmental origin of glucoCEST signal is still an ongoing debate. To address this crucial question, we propose in this study to use diffusion-weighted CEST-MRS in order to disentangle extracellular/extravascular and intracellular contributions to the glucoCEST signal. D-glucose and 2-deoxy-D-glucose were injected intravenously and kinetics of glucoCEST signal were measured over time. The comparison of kinetics acquired with and without diffusion grandients showed that 2-deoxy-D-glucose glucoCEST signal was dominated by intracellular contribution, contrarily of D-glucose. This study could constitute a major step toward glucoCEST quantification and could be beneficial for several applications, especially to study energy metabolism defects in neurodegenerative disorders.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords