Abstract #0379

Magnetic resonance imaging of cationic compounds using their proton exchange modulating effect

Zheng Han^1,2, Safiya Aafreen³, Yang Zhou^1,2,4, Chongxue Bie^1,2, Jiadi Xu^1,2, Lei Zheng⁵, Peter C.M. van Zijl^1,2, and Guanshu Liu^1,2

¹Radiology, Johns Hopkins University, Baltimore, MD, United States, ²F.M Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, ³Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ⁵Oncology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Here we report a novel approach to detect non-labeled cationic compounds, named modulated saturation transfer (MOST)-MRI, based on their effect of modulating the exchange rate of surrounding exchangeable protons. MOST-MRI was able to detect polyethylenimine (PEI600, M.W. = 600 Da), at a high sensitivity (μM or μg/mL range) through its quenching effects on surrounding fast-exchanging protons. In animals, MOST-MRI detected the tumor uptake of PEI600 that was injected intratumorally at a low dose (50 μg/kg b.w.), indicating the potential of MOST-MRI for label-free imaging guidance that is needed for the development and clinical translation of cationic gene delivery systems.

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