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Abstract #0380

Diagnostic Performance of Diffusion Weighted Imaging, Arterial Spin Labeling and Amide Proton Transfer in sub-classifications of gliomas

DiaoHan Xiong1, Rui Wang1, Tao Wen1, TieJun Gan1, PengFei Wang1, XinYing Ren1, YuJing Li1, Jing Zhang1, and Kai Ai2
1Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi'an, China


To assess the diagnostic performance of Amide Proton Transfer (APT) and Arterial Spin Labeling (ASL) for distinguishing different sub-classifications of gliomas in comparison with Diffusion Weighted Imaging (DWI). Forty patients underwent sequences including T1W enhancement, DWI, APT and 3D-pCASL. ADCmean, ADCmean-to-ADCNAWM ratio, APTmean, APTmean-to-APTNAWM ratio, regional cerebral blood flow (rCBF) and rCBFmean-to-rCBFNAWM ratio are calculated. The results showed that diagnostic accuracy of APTmean was superior in distinguishing sub-classifications of gliomas than other parameters. We concluded that APT can be used in predicting sub-classification of gliomas based on WHO CNS5, providing more valuable supplementary information for early treatment guidance and surgery.

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