Diagnostic Performance of Diffusion Weighted Imaging, Arterial Spin Labeling and Amide Proton Transfer in sub-classifications of gliomas

Synopsis

To assess the diagnostic performance of Amide Proton Transfer (APT) and Arterial Spin Labeling (ASL) for distinguishing different sub-classifications of gliomas in comparison with Diffusion Weighted Imaging (DWI). Forty patients underwent sequences including T1W enhancement, DWI, APT and 3D-pCASL. ADC_mean, ADC_mean-to-ADC_NAWM ratio, APT_mean, APT_mean-to-APT_NAWM ratio, regional cerebral blood flow (rCBF) and rCBF_mean-to-rCBF_NAWM ratio are calculated. The results showed that diagnostic accuracy of APT_mean was superior in distinguishing sub-classifications of gliomas than other parameters. We concluded that APT can be used in predicting sub-classification of gliomas based on WHO CNS5, providing more valuable supplementary information for early treatment guidance and surgery.