To assess the diagnostic performance of Amide Proton Transfer (APT) and Arterial Spin Labeling (ASL) for distinguishing different sub-classifications of gliomas in comparison with Diffusion Weighted Imaging (DWI). Forty patients underwent sequences including T1W enhancement, DWI, APT and 3D-pCASL. ADCmean, ADCmean-to-ADCNAWM ratio, APTmean, APTmean-to-APTNAWM ratio, regional cerebral blood flow (rCBF) and rCBFmean-to-rCBFNAWM ratio are calculated. The results showed that diagnostic accuracy of APTmean was superior in distinguishing sub-classifications of gliomas than other parameters. We concluded that APT can be used in predicting sub-classification of gliomas based on WHO CNS5, providing more valuable supplementary information for early treatment guidance and surgery.
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