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Abstract #0390

Molecular MRI and PET Imaging Detect Biomarkers of Neuroinflammation in Contusion Injured Spinal Cord

Chaoqi Mu1, Jamie L Reed1, Mohammed Noor Tantawy1, Feng Wang1, Li Min Chen1, and John C Gore1
1Vanderbilt University Institute of Imaging Science & Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States


Spinal cord injury (SCI) severity/recovery are influenced by complex pathological mechanisms. We used CEST/NOE MR and TSPO PET imaging to evaluate longitudinal molecular changes associated with neuroinflammation in a lumbar contusion SCI rodent model. The NOE(-1.6 ppm) peak amplitude significantly decreased and the CEST(3.5 ppm) peak amplitude increased in SCI rats, 1-week post-injury. Similarly, we detected significant increase in the uptake of a TSPO-targeting PET radiotracer at the SCI epicenter. The CEST/NOE pools can be linked to neuroinflammatory activity associated with glutamate release. The results indicate that CEST/NOE MRI measurements provide complementary information to TSPO PET measurement in SCI.

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