Abstract #0392

Identifying diffusion model biomarkers for inflammation in human traumatic spinal cord injury

Sarah Rosemary Morris^1,2,3, Taylor Swift-LaPointe², Andrew Yung^1,3,4, Valentin Prevost^1,3,4, Shana George¹, Andrew Bauman⁴, Piotr Kozlowski^1,2,3,4, Farah Samadi^1,5, Caron Fournier^1,5, Lisa Parker⁶, Kevin Dong¹, Femke Streijger¹, Veronica Hirsch-Reinshagen^1,5,6, G.R. Wayne Wayne Moore^1,5,6, Brian K Kwon^1,7, and Cornelia Laule^1,2,3,5

¹International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, ²Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴Faculty of Medicine, UBC MRI Research Centre, Vancouver, BC, Canada, ⁵Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Vancouver General Hospital, Vancouver, BC, Canada, ⁷Orthopaedics, University of British Columbia, Vancouver, BC, Canada

Synopsis

We investigated the relationship between diffusion model biomarkers and inflammatory cells, as measured by HLA-DR and CD68 histological staining for activated microglia and macrophages, after human traumatic spinal cord injury. Fractional anisotropy decreases and radial and mean diffusivity increases were strongly correlated with the presence of activated microglia and macrophages. ActiveAx-derived intra-cellular volume fraction and axon density decreased while axon diameter increased. Fiber fraction from Diffusion Basis Spectrum Imaging decreased and while hindered fraction increased in the presence of inflammation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.