Corpus callosum lesions are associated with worse cognitive performance in cerebral amyloid angiopathy
Whitney Freeze1, Maria Clara Zanon Zotin2,3, Ashley Scherlek2, Valentina Perosa2, Andrew Warren2, Louise van der Weerd1, Dorothee Schoemaker Marcotte2, Mitchell Horn2, Edip Gurol2, Elif Gokcal2, Brian Bacskai2, Anand Viswanathan2, Steven Greenberg2, Yael Reijmer4, and Susanne van Veluw1,2
1Leiden University Medical Center, Leiden, Netherlands, 2Massachusetts General Hospital, Boston, MA, United States, 3Ribeirão Preto medical School, São Paulo, Brazil, 4University Medical Center Utrecht, Utrecht, Netherlands
We assessed the contribution of small vessel disease lesions in the corpus callosum (CC) to vascular cognitive impairment in cerebral amyloid angiopathy (CAA). A total number of 21 CC lesions was found in 19/65 (29%) CAA patients. CC lesion presence was associated with reduced microstructural white matter integrity within the CC and in the whole brain white matter. Patients with CC lesions performed significantly worse on multiple cognitive domains compared to those without CC lesions after correcting for relevant covariates. Together, our findings suggest that CC lesions independently contribute to cognitive impairment through strategic microstructural disruption of white matter tracts.
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