We assessed the contribution of small vessel disease lesions in the corpus callosum (CC) to vascular cognitive impairment in cerebral amyloid angiopathy (CAA). A total number of 21 CC lesions was found in 19/65 (29%) CAA patients. CC lesion presence was associated with reduced microstructural white matter integrity within the CC and in the whole brain white matter. Patients with CC lesions performed significantly worse on multiple cognitive domains compared to those without CC lesions after correcting for relevant covariates. Together, our findings suggest that CC lesions independently contribute to cognitive impairment through strategic microstructural disruption of white matter tracts.
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