Abstract #0393

Corpus callosum lesions are associated with worse cognitive performance in cerebral amyloid angiopathy

Whitney Freeze¹, Maria Clara Zanon Zotin^2,3, Ashley Scherlek², Valentina Perosa², Andrew Warren², Louise van der Weerd¹, Dorothee Schoemaker Marcotte², Mitchell Horn², Edip Gurol², Elif Gokcal², Brian Bacskai², Anand Viswanathan², Steven Greenberg², Yael Reijmer⁴, and Susanne van Veluw^1,2

¹Leiden University Medical Center, Leiden, Netherlands, ²Massachusetts General Hospital, Boston, MA, United States, ³Ribeirão Preto medical School, São Paulo, Brazil, ⁴University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

We assessed the contribution of small vessel disease lesions in the corpus callosum (CC) to vascular cognitive impairment in cerebral amyloid angiopathy (CAA). A total number of 21 CC lesions was found in 19/65 (29%) CAA patients. CC lesion presence was associated with reduced microstructural white matter integrity within the CC and in the whole brain white matter. Patients with CC lesions performed significantly worse on multiple cognitive domains compared to those without CC lesions after correcting for relevant covariates. Together, our findings suggest that CC lesions independently contribute to cognitive impairment through strategic microstructural disruption of white matter tracts.

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