Laminar-specific fMRI with CBV-sensitive VASO can address neuroscience research questions on directional information processing within and across brain areas. However, conventional 0.8mm resolutions cannot Nyquist sample the individual layer-groups of interest (e.g. Layers II/III from layer IVc in V1). Here we implement, evaluate, and apply a 0.39-0.45mm (iso.) VASO protocol on the NextGen 7T scanner to resolve layer-features that could not be resolved in humans before. We find that 0.45 mm protocols are possible if the sequence parameters of EPI-segmentation and GRAPPA acceleration are differently optimized than one would do for conventional fMRI protocols.
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