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Abstract #0397

Sub-0.1 microliter CBV fMRI on the Next Generation 7T scanner

David A Feinberg1,2,3, Salvatore Torrisi1,2, Alexander JS Beckett1,2, Rüdiger Stirnberg4, Tony Stöcker4, Philipp Ehses4, and Renzo Huber3
1Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States, 2Advanced MRI Technologies, Sebastopol, CA, United States, 3Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 4German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany


Laminar-specific fMRI with CBV-sensitive VASO can address neuroscience research questions on directional information processing within and across brain areas. However, conventional 0.8mm resolutions cannot Nyquist sample the individual layer-groups of interest (e.g. Layers II/III from layer IVc in V1). Here we implement, evaluate, and apply a 0.39-0.45mm (iso.) VASO protocol on the NextGen 7T scanner to resolve layer-features that could not be resolved in humans before. We find that 0.45 mm protocols are possible if the sequence parameters of EPI-segmentation and GRAPPA acceleration are differently optimized than one would do for conventional fMRI protocols.

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