Evaluating the capabilities and challenges of layer-fMRI VASO at 3T
Renzo Huber1, Lisa Kronbichler2, Rüdiger Stirnberg3, Luca Vizioli4, Philipp Ehses3, Tony Stöcker3, Sara Fernández-Cabello5, Benedikt A Poser1, and Martin Kronbichler6,7
1FPN, Uni Maastricht, Maastricht, Netherlands, 2Department of Psychiatry, Psychotherapy and Psychosomatics, Christian‐Doppler Medical Centre, PMU, Salzburg, Austria, 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 4Department of Radiology, University of Minnesota, Center for Magnetic Resonance Research, Minneapolis, MN, United States, 5Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, Uni Oslo, Oslo, Norway, 6Neuroscience Institute, Christian Doppler Medical Centre, PMU, Salzburg, Austria, 7Centre for Cognitive Neuroscience & Department of Psychology, University of Salzburg, Salzburg, Austria
Sub-millimeter functional imaging at ultra high field (UHF) strengths can capture cortical layer-specific functional information flow within and across brain systems. However, UHF scanners are only available to appr. 100 privileged imaging centers, globally. In this work, we implement, characterise and apply a CBV-sensitive VASO sequence setup for widely accessible 3T scanners. We find that the longer T2*, and shorter T1 relaxation times at 3T can account for some of the lower z-magnetization in the inversion-recovery VASO sequence compared to 7T and 9.4T. We conclude that layer-fMRI VASO is applicable without too much further ado at 3T.
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