Molecular-enriched functional connectivity in the human brain using multi-band multi-echo simultaneous ASL/BOLD fMRI
Ottavia Dipasquale1, Alexander Cohen2, Daniel Martins1, Fernando Zelaya1, Federico Turkheimer1, Mattia Veronese1, Steve Williams1, Baolian Yang3, Suchandrima Banarjee4, and Yang Wang2
1Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, 2Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 3GE Healthcare, Waukesha, WI, United States, 4GE Healthcare, Menlo Park, CA, United States
This work is a proof of concept for the integration of ASL fMRI and molecular imaging using REACT, a novel analytical strategy that enriches functional data with the molecular information on the neurotransmitter distribution density. We applied REACT to high-resolution, whole-brain simultaneous ASL/BOLD data to estimate BOLD- and perfusion-weighted (PW)-based functional connectivity maps related to specific molecular systems and compared the results from the two fMRI modalities, showing very similar patterns of molecular-enriched functional connectivity. Our findings show that the PW signal is as informative as BOLD in terms of detection of functional circuits associated to specific molecular pathways.
This abstract and the presentation materials are available to members only;
a login is required.