This work is a proof of concept for the integration of ASL fMRI and molecular imaging using REACT, a novel analytical strategy that enriches functional data with the molecular information on the neurotransmitter distribution density. We applied REACT to high-resolution, whole-brain simultaneous ASL/BOLD data to estimate BOLD- and perfusion-weighted (PW)-based functional connectivity maps related to specific molecular systems and compared the results from the two fMRI modalities, showing very similar patterns of molecular-enriched functional connectivity. Our findings show that the PW signal is as informative as BOLD in terms of detection of functional circuits associated to specific molecular pathways.
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