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Abstract #0401

Resting state fluctuations in BOLD fMRI might not systematically reflect measures of cerebrovascular physiology between or within subjects

Stefano Moia1, Gang Chen2, Eneko Uruñuela1, Rachael C. Stickland3, Maite Termenon1, César Caballero-Gaudes1, and Molly G. Bright3,4
1Basque Center on Cognition, Brain and Language, Donostia, Spain, 2NIMH/NIH/HHS, Bethesda, MD, United States, 3Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 4Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States


Resting State Fluctuations (RSF) metrics are frequently associated with vascular and physiological factors, to the point of being suggested as alternative estimates of cerebrovascular reactivity (CVR) and as tools for fMRI data calibration. Using a densely sampled fMRI dataset, we demonstrate high individual variability in the inter-session relationships between RSF metrics and CVR. Moreover, while physiological factors such as blood pressure show a significant relationship with CVR, they do not with common RSF metrics. These results indicate that RSF parameters might not be suitable alternatives for CVR, and may not properly account for inter-individual physiological variations in BOLD fMRI data.

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