Resting State Fluctuations (RSF) metrics are frequently associated with vascular and physiological factors, to the point of being suggested as alternative estimates of cerebrovascular reactivity (CVR) and as tools for fMRI data calibration. Using a densely sampled fMRI dataset, we demonstrate high individual variability in the inter-session relationships between RSF metrics and CVR. Moreover, while physiological factors such as blood pressure show a significant relationship with CVR, they do not with common RSF metrics. These results indicate that RSF parameters might not be suitable alternatives for CVR, and may not properly account for inter-individual physiological variations in BOLD fMRI data.
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