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Abstract #0405

Skeletal muscle acetylcarnitine during submaximal exercise and recovery: Interleaved 1H/31P MRS 7T pilot study

Radka Klepochová1,2, Fabian Niess2, Martin Meyerspeer3, Siegfried Trattnig2,4, Michael Krebs1, Alexandra Kautzky-Willer1, Michael Leutner1, and Martin Krššák1,2
1Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 2High-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 3High-Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 4Christian Doppler Laboratory for Clinical Molecular MR Imaging (MOLIMA), Christian Doppler Laboratory, Vienna, Austria


The study aimed to explore the behavior of skeletal muscle acetylcarnitine and phosphocreatine during submaximal plantar flexion exercise using interleaved 1H/31P MRS at 7T. Acetylcarnitine decreased to steady state during the exercise, increased back to initial levels in early recovery period and started to decline during later phase of recovery. Studies including more volunteers and patients with broader range of metabolic conditions and physical fitness will be necessary for detailed quantitative analysis.

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