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Abstract #0406

Exploratory study of relationships between [18F] Sodium fluoride PET metabolic bone measures and MRI bone porosity index in the tibial tuberosity

Marco Barbieri*1, Lauren Watkins*1, Bryan Haddock2, Garry E. Gold1,3, and Feliks Kogan1
1Radiology, Stanford University, Stanford, CA, United States, 2Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 3Bioengineering, Stanford University, Stanford, CA, United States


Molecular information derived from dynamic [18F]NaF PET imaging holds promise to study bone remodeling in bone and joint disorders. The porosity index (PI), based on ultra-short echo-time (uTE) MRI, has been proposed to study bone porosity in clinically valuable acquisition times. We explored the association between bone metabolic and porosity information in the tibial tuberosity in a cohort of 10 subjects with knee OA using hybrid PET-MRI imaging. We found a moderate negative correlation between the metabolic bone remodeling (Ki) and the porosity index. These promising results may highlight a new tool to unveil unknown pathways in musculoskeletal disease pathophysiology.

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