Molecular information derived from dynamic [18F]NaF PET imaging holds promise to study bone remodeling in bone and joint disorders. The porosity index (PI), based on ultra-short echo-time (uTE) MRI, has been proposed to study bone porosity in clinically valuable acquisition times. We explored the association between bone metabolic and porosity information in the tibial tuberosity in a cohort of 10 subjects with knee OA using hybrid PET-MRI imaging. We found a moderate negative correlation between the metabolic bone remodeling (Ki) and the porosity index. These promising results may highlight a new tool to unveil unknown pathways in musculoskeletal disease pathophysiology.
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