We apply a probabilistic deep learning model to perform image super-resolution on magnetic resonance (MR) images. Our results show that the model is capable of high performance in MR; we upsample low resolution images of the distal tibia to 2x initial spatial resolution–equivalent to capturing 4x fewer samples in K-space–with the goal of reconstructing details in the trabecular architecture. We validate our results by comparing trabecular bone microstructure metrics across high-resolution ground truth, model-reconstructed, and low-resolution input images. By drastically reducing scan time for high-resolution imaging, these methods have the potential to make MRI assessment of bone strength clinically viable.
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