Abstract #0408

Early Chemotherapeutic Response Evaluation In Ewing Sarcoma Using Diffusion Weighted MRI

Esha Baidya Kayal¹, Jayendra Tiru Alampally², Raju Sharma³, Sameer Bakhshi³, Amit Mehndiratta^1,3, Rakesh Kumar³, Chandrashekhara SH³, Manisha Jana³, Ashu Seith Bhalla³, Mehar Chand Sharma³, Asit Ranjan Mridha³, Sreenivas Vishnubhatla³, and Devasenathipathy Kandasamy³

¹Indian Institute of Technology Delhi, Delhi, India, ²Krishna Imaging & Diagnostics, Telengana, India, ³All India Institute of Medical Sciences Delhi, Delhi, India

Synopsis

The objective of this prospective study was to assess the role of diffusion weighted MRI for early evaluation of chemotherapy response in patients with Ewing sarcoma with RECIST 1.1 criteria correlation. Absolute apparent diffusion coefficient (ADC), normalized ADC (nADC) and tumor diameter at baseline and after 1^st cycle of chemotherapy were assessed for early detection of chemotherapy response in 16 patients. Results showed, baseline nADC and after 1^st chemotherapy cycle, relative percentage change (Δ%) in nADC & tumor-size were significant and observed to be useful markers of early chemotherapeutic response (AUC=0.700, 0.750, 0.938) in Ewing sarcoma.

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