The objective of this prospective study was to assess the role of diffusion weighted MRI for early evaluation of chemotherapy response in patients with Ewing sarcoma with RECIST 1.1 criteria correlation. Absolute apparent diffusion coefficient (ADC), normalized ADC (nADC) and tumor diameter at baseline and after 1st cycle of chemotherapy were assessed for early detection of chemotherapy response in 16 patients. Results showed, baseline nADC and after 1st chemotherapy cycle, relative percentage change (Δ%) in nADC & tumor-size were significant and observed to be useful markers of early chemotherapeutic response (AUC=0.700, 0.750, 0.938) in Ewing sarcoma.
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