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Abstract #0408

Early Chemotherapeutic Response Evaluation In Ewing Sarcoma Using Diffusion Weighted MRI

Esha Baidya Kayal1, Jayendra Tiru Alampally2, Raju Sharma3, Sameer Bakhshi3, Amit Mehndiratta1,3, Rakesh Kumar3, Chandrashekhara SH3, Manisha Jana3, Ashu Seith Bhalla3, Mehar Chand Sharma3, Asit Ranjan Mridha3, Sreenivas Vishnubhatla3, and Devasenathipathy Kandasamy3
1Indian Institute of Technology Delhi, Delhi, India, 2Krishna Imaging & Diagnostics, Telengana, India, 3All India Institute of Medical Sciences Delhi, Delhi, India


The objective of this prospective study was to assess the role of diffusion weighted MRI for early evaluation of chemotherapy response in patients with Ewing sarcoma with RECIST 1.1 criteria correlation. Absolute apparent diffusion coefficient (ADC), normalized ADC (nADC) and tumor diameter at baseline and after 1st cycle of chemotherapy were assessed for early detection of chemotherapy response in 16 patients. Results showed, baseline nADC and after 1st chemotherapy cycle, relative percentage change (Δ%) in nADC & tumor-size were significant and observed to be useful markers of early chemotherapeutic response (AUC=0.700, 0.750, 0.938) in Ewing sarcoma.

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