Abstract #0409

Detection of a new resonance in human calf muscle in vivo at 7.0T using the down-field MRS

Ravi Prakash Reddy Nanga¹, Mark Elliott¹, Neil Wilson¹, Sophia Swago², Walter Witschey¹, and Ravinder Reddy¹

¹Radiology, Center for Advance Metabolic Imaging in Precision Medicine, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, ²Bioengineering, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

We have detected a resonance that was not reported previously, with a chemical shift of ~9.7ppm occurring in down-field MRS (DFMRS) from the human calf muscle in vivo. Based on phantom data, we speculate that the contribution to this broad peak might be from nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). This is for the first time that this peak is observed and reported from the down-field spectra. It seems to be very specific to calf muscle and has not been identified from the down-field spectra of human brain in vivo, suggesting that it is a feature of muscle metabolism.

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