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Abstract #0409

Detection of a new resonance in human calf muscle in vivo at 7.0T using the down-field MRS

Ravi Prakash Reddy Nanga1, Mark Elliott1, Neil Wilson1, Sophia Swago2, Walter Witschey1, and Ravinder Reddy1
1Radiology, Center for Advance Metabolic Imaging in Precision Medicine, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, 2Bioengineering, University of Pennsylvania, Philadelphia, PA, United States


We have detected a resonance that was not reported previously, with a chemical shift of ~9.7ppm occurring in down-field MRS (DFMRS) from the human calf muscle in vivo. Based on phantom data, we speculate that the contribution to this broad peak might be from nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). This is for the first time that this peak is observed and reported from the down-field spectra. It seems to be very specific to calf muscle and has not been identified from the down-field spectra of human brain in vivo, suggesting that it is a feature of muscle metabolism.

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