Evidence of a cortical hypoperfusion spreading following local ultrasound Blood Brain Barrier opening in the rat brain.
Wafae Labriji1, Julien Clauzel1, Carla Cirillo1, Maxime Lafond2, Cyril Lafon2, Lydiane Hirschler3, Jan Warnking3, Emmanuel L. Barbier3, Isabelle Loubinoux1, and Franck Desmoulin1,4
1ToNIC, Toulouse NeuroImaging Center (UMR 1214 - Inserm / UPS), Toulouse, France, 2LabTAU, Inserm, Centre Léon Bérard, Université Lyon 1, Lyon, France, 3GIN, Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, Grenoble, France, 4CREFRE, Inserm, Université Toulouse III Paul Sabatier, ENVT, Toulouse, France
The use of ultrasound combined with microbubbles to open the blood-brain barrier is an increasingly common method in clinical and preclinical research. This work describes the effect of this BBB opening method on brain perfusion in rats, using pCASL sequence. Surprisingly, through a dynamic analysis, we observed a long time hypoperfusion spreading in the brain cortex following sonication. A similar phenomenon has been described in studies where cortical spreading depression (CSD) has been induced.
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