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Abstract #0421

Differential information of perfusion and diffusion MRI following traumatic spinal cord injury in the rat.

Briana P Meyer1, Seung-Yi Lee1, and Matthew D Budde2
1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States


Spinal cord tissue perfusion plays a central role in the acute care of spinal cord injury (SCI). We previously optimized pseudo-continuous arterial spin labeling (pCASL) MRI for the rat spinal cord. This work represents the first longitudinal study combining pCASL and filtered diffusion weighted MRI to examine the relationship between spinal cord blood flow and filtered axial diffusivity following a rat model of SCI. This work reveals unique and differing spatiotemporal dynamics between the two contrasts.

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