Meeting Banner
Abstract #0420

Impairments in cerebral blood flow and cerebrovascular reactivity in the APP23 mouse model of cerebral amyloidosis

Leon P Munting1, Mariel G Kozberg1, Lydiane Hirschler2, Jan M Warnking3, Emmanuel L Barbier3, Andre van der Kouwe4, Joseph B Mandeville4, Christian T Farrar4, Steven M Greenberg1, Brian J Bacskai1, and Susanne J van Veluw1
1Massachusetts General Hospital, BOSTON, MA, United States, 2Leiden University Medical Center, Leiden, Netherlands, 3Grenoble Institut des Neurosciences, Grenoble, France, 4Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States


Patients with cerebral amyloid angiopathy (CAA) have accumulations of amyloid-beta in the cerebral vasculature, which ultimately lead to stroke and dementia. MRI markers of CAA include microbleeds and reduced cerebrovascular reactivity (CVR). The APP23 mouse model with vascular amyloid-beta accumulation is known to have microbleeds and reduced cerebral blood flow (CBF). Here, using pseudo-Continuous Arterial Spin Labeling (pCASL)-MRI with a 10 % CO2 stimulation, we show that besides lower CBF, APP23 mice also have reduced CVR. Furthermore, in our data, a higher microbleed count was associated with lower CBF, but not with CVR.

This abstract and the presentation materials are available to members only; a login is required.

Join Here