Patients with cerebral amyloid angiopathy (CAA) have accumulations of amyloid-beta in the cerebral vasculature, which ultimately lead to stroke and dementia. MRI markers of CAA include microbleeds and reduced cerebrovascular reactivity (CVR). The APP23 mouse model with vascular amyloid-beta accumulation is known to have microbleeds and reduced cerebral blood flow (CBF). Here, using pseudo-Continuous Arterial Spin Labeling (pCASL)-MRI with a 10 % CO2 stimulation, we show that besides lower CBF, APP23 mice also have reduced CVR. Furthermore, in our data, a higher microbleed count was associated with lower CBF, but not with CVR.
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