Abstract #0420

Impairments in cerebral blood flow and cerebrovascular reactivity in the APP23 mouse model of cerebral amyloidosis

Leon P Munting¹, Mariel G Kozberg¹, Lydiane Hirschler², Jan M Warnking³, Emmanuel L Barbier³, Andre van der Kouwe⁴, Joseph B Mandeville⁴, Christian T Farrar⁴, Steven M Greenberg¹, Brian J Bacskai¹, and Susanne J van Veluw¹

¹Massachusetts General Hospital, BOSTON, MA, United States, ²Leiden University Medical Center, Leiden, Netherlands, ³Grenoble Institut des Neurosciences, Grenoble, France, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States

Synopsis

Patients with cerebral amyloid angiopathy (CAA) have accumulations of amyloid-beta in the cerebral vasculature, which ultimately lead to stroke and dementia. MRI markers of CAA include microbleeds and reduced cerebrovascular reactivity (CVR). The APP23 mouse model with vascular amyloid-beta accumulation is known to have microbleeds and reduced cerebral blood flow (CBF). Here, using pseudo-Continuous Arterial Spin Labeling (pCASL)-MRI with a 10 % CO₂ stimulation, we show that besides lower CBF, APP23 mice also have reduced CVR. Furthermore, in our data, a higher microbleed count was associated with lower CBF, but not with CVR.

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