Abstract #0419

Impaired brain perfusion and cerebrovascular reactivity in the zQ175 mouse model of Huntington’s Disease, a longitudinal pCASL-MRI study

Tamara Vasilkovska ^1,2, Verdi Vanreusel¹, Somaie Salajeghe¹, Johan van Audekerke^1,2, Lydiane Hirschler³, Dorian Pustina⁴, Roger Cachope⁴, Haiying Tang⁴, Longbin Liu⁴, Celia Dominguez⁴, Ignacio Munoz-Sanjuan⁴, Annemie Van der Linden^1,2, and Marleen Verhoye^1,2

¹Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium, ²µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium, ³C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, ⁴CHDI Management/CHDI Foundation, Princeton, NJ, United States

Synopsis

Abnormal cerebral vasculature and consequent diminished cerebrovascular function have been shown to play a role in Huntington’s Disease (HD). However, how these impairments reflect on cerebral blood flow (CBF) dynamics and vascular reactivity (CVR) have been poorly understood. Towards this, we performed a longitudinal study measuring CBF and CVR, using pCASL, in the zQ175 KI Huntington’s disease (HD) mouse model at pre-manifest (3/4.5 months), disease onset (6 months) and manifest (9 months) stage. Our results demonstrate decreased CBF under CO₂ challenge at disease onset and decreased CVR in manifest HD stage in the zQ175 KI mice compared to age-matched controls.

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