Abnormal cerebral vasculature and consequent diminished cerebrovascular function have been shown to play a role in Huntington’s Disease (HD). However, how these impairments reflect on cerebral blood flow (CBF) dynamics and vascular reactivity (CVR) have been poorly understood. Towards this, we performed a longitudinal study measuring CBF and CVR, using pCASL, in the zQ175 KI Huntington’s disease (HD) mouse model at pre-manifest (3/4.5 months), disease onset (6 months) and manifest (9 months) stage. Our results demonstrate decreased CBF under CO2 challenge at disease onset and decreased CVR in manifest HD stage in the zQ175 KI mice compared to age-matched controls.
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