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Abstract #0418

Whole brain mapping of transcranial electrical stimulation-induced effects by BOLD-fMRI in rats

Mihaly Voroslakos1, Tanzil Mahmud Arefin2, Jiangyang Zhang2, Leeor Alon2, and Gyorgy Buzsaki1
1Neuroscience Institute, NYU Langone Health, New York, NY, United States, 2Department of Radiology, NYU School of Medicine, New York, NY, United States


Transcranial Electrical Stimulation (TES) is a noninvasive method that can modulate neuronal activity. Despite 20 years of intensive research, the basic mechanisms, and the extent of TES influence on brain functions is still not well understood. To gain a better understanding of the TES effects, we combined neurostimulation with BOLD-fMRI in rats. We have designed an MR-compatible TES setup, including a deuterium-based stimulation electrode system. Our results revealed BOLD responses to TES and altered cortical and cortico-subcortical network responses induced by a variety of stimulation patterns and intensities.

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