We have recently developed the spatial domain, Fast LIpid signal Processing (FLIP) algorithm to remove subcutaneous lipid signals in MRSI. Practical application of FLIP to 3D EPSI was challenging due to the need for long processing times. We present an updated algorithm, named FLIP-COIL, which significantly reduces the processing times utilizing receive coil senstivity profiles. Algorithms including FLIP, FLIP-COIL, as well as PGA, HSVD and L2 are compared in 3D EPSI of ten subjects. This study demostrates that the FLIP-COIL approach can drastically reduce processing time with favorable performance of lipid removal in 3D EPSI over existing other algorithms.
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