Correction of diffusion pore imaging (DPI) data in the presence of extraporal water and transmembrane water exchange
Dominik Ludwig1,2, Frederik B. Laun3, Karel D. Klika4, Julian Rauch1,2, Mark E. Ladd1,2,5, Peter Bachert1,2, and Tristan A. Kuder1
1Deparment of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 4Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Faculty of Medicine, Heidelberg University, Heidelberg, Germany
Diffusion pore imaging might open a new window into pathologies by providing histology-like information non-invasively by estimating pore size and shape distributions. For current pore imaging approaches, closed pores filled with an NMR visible diffusing medium are assumed, while extraporal components and exchange are neglected, which limits applicability. We propose a method based on Gaussian phase approximation to suppress effects of extraporal fluids and transmembrane water exchange and compare the approach to a filter-based method. Thus, one main obstacle for in vivo applications is reduced, the required high gradient amplitudes may be obtained using local gradient coils in the future.
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