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Abstract #0458

White matter changes in myelin, iron and R2* in Alzheimer's disease

Lindsay Munroe1, Azhaar Ashraf1, Antigoni Ekonomou1, Harold Parkes1, Claire Troakes1, and Po-Wah So1
1Neuro-imaging, King's College London, London, United Kingdom


Brain iron dyshomeostasis/iron overload has been observed in Alzheimer's disease (AD). Being sensitive to the presence of iron, magnetic resonance imaging (MRI), is often used to study the role of iron in disease. In this study, we determined group differences in iron, R2* and myelin, acquired from the same ex-vivo mid-temporal gyri samples from AD and cognitively normal (CN) subjects. We observed decreased myelin and iron in white matter AD compared to CN. These white matter changes are likely due to a loss of iron-rich oligodendrocytes and demyelination during AD pathogenesis.

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