Alzheimer’s is an irreversible degenerative brain disease. Current clinical MRI is capable of reporting severe brain atrophy, but fails to recognize earlier biomarkers associated with more subtle microstructural changes. Microstructural MRI techniques such as DTI, MAP-MRI, NODDI, MWF, and BPF are promising to address this challenge and may sensitively detect and distinguish tissue degeneration, tauopathies, and beta amyloid plaques. The capability of these techniques was investigated in post-mortem human temporal lobe specimens at high resolution and high image quality. Prominent findings seen were distinct differences between relaxivity and diffusivity metrics, and striking differences between DTI and MAP-MRI anisotropy metrics.
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