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Abstract #0462

Functional eigenvector centrality dynamics are related to amyloid deposition in preclinical Alzheimer’s Disease

Luigi Lorenzini1, Ingala Silvia1, Lyduine E Collij1, Betty Tijms2, Henk JMM Mutsaerts 1,3, Viktor Wottschel 1, Sven Haller4,5, Kaj Blennow 6,7, Giovanni Frisoni8,9, Gael Chételat 10, Pierre Payoux 11,12, Pablo Lage-Martinez 13, Adam Waldman 14,15, Joanna Wardlaw 14,16, Craig Ritchie17, Juan Domingo Gispert 18,19,20,21, Pieter Jelle Visser 2,22,23, Philip Scheltens 2, Barkhof Frederik1, and Alle Meije Wink 1
1Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Centre, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, The Netherlands, Amsterdam, Netherlands, 2Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands, Amsterdam, Netherlands, 3Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium, Ghent, Belgium, 4CIRD Centre d’Imagerie Rive Droite, Geneva, Switzerland, Geneva, Switzerland, 5Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 6Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Sweden, Gothenburg, Sweden, 7Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden, Mölndal, Sweden, 8aboratory Alzheimer’s Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy, Brescia, Italy, 9University Hospitals and University of Geneva, Geneva, Switzerland, Geneva, Switzerland, 10Université de Normandie, Unicaen, Inserm, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", institut Blood-and-Brain @ Caen-Normandie, Cyceron, 14000 Caen, France, Caen, France, 11Department of Nuclear Medicine, Toulouse CHU, Purpan University Hospital, Toulouse, France, Toulouse, France, 12Toulouse NeuroImaging Center, University of Toulouse, INSERM, UPS, Toulouse, France, Toulouse, France, 13Centro de Investigación y Terapias Avanzadas, Neurología, CITA‐Alzheimer Foundation, San Sebastián, Spain, San Sebastián, Spain, 14Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK, Edinburgh, Scotland, 15Department of Medicine, Imperial College London, London, UK, London, United Kingdom, 16UK Dementia Research Institute at Edinburgh, University of Edinburgh, UK, Edinburgh, Scotland, 17Centre for Dementia Prevention, The University of Edinburgh, Scotland, UK, Edinburgh, Scotland, 18Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain, Barcelona, Spain, 19CIBER Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain, Madrid, Spain, 20IMIM (Hospital del Mar Medical Research Institute), Barcelona Spain, Barcelona, Spain, 21Universitat Pompeu Fabra, Barcelona, Spain, Barcelona, Spain, 22Alzheimer Center Limburg, Department of Psychiatry & Neuropsychology, School of Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands, Maastricht, Netherlands, 23Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden


Recent evidence suggests that amyloid deposition in the brain follows — and subsequently affects — temporal variability of neuronal activity and functional connectivity. Temporal variability in functional brain network properties connote changes in participation of functional hubs in different subnetworks. We confirm previous findings of alterations of functional eigenvector centrality (EC) in relation to amyloid, and demonstrate that those regions show altered dynamic EC profiles with lower variability over time, hence lower network integration.

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