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Abstract #0463

Subject-specific features of excitation/inhibition profiles in neurodegenerative diseases

Anita Monteverdi1,2, Fulvia Palesi2, Claudia AM Gandini Wheeler-Kingshott1,2,3, and Egidio D'Angelo1,2
1Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy, 2Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 3NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom


The Virtual Brain (TVB) is a novel modeling platform to simulate whole-brain dynamics starting from individual structural and functional connectivity. In this work, we performed TVB simulations in neurodegenerative diseases (i.e. Alzheimer’s disease, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis) providing a unique description of the excitatory/inhibitory balance at single-subject level. TVB-derived biophysical parameters were different among clinical phenotypes, presented an association with neuropsychological domains and improved discriminative power between clinical conditions. Overall, this work suggests a novel TVB-based approach for future personalized diagnosis and therapy in neurodegenerative diseases, providing a subject-specific description of excitation/inhibition profiles.

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