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Abstract #0464

Microscopic fractional anisotropy may be sensitive to unilateral hippocampal abnormalities in temporal lobe epilepsy

Nico J. J. Arezza1,2, Jorge G. Burneo3, Ali R. Khan1,2,4, and Corey A. Baron1,2,4
1Medical Biophysics, Western University, London, ON, Canada, 2Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada, 3Epilepsy Program, Clinical Neurological Sciences, Western University, London, ON, Canada, 4School of Biomedical Engineering, Western University, London, ON, Canada


Drug-resistant temporal lobe epilepsy (TLE) can often be treated surgically, but successful intervention depends on the use of imaging to localize the epileptic focus. Here, microscopic fractional anisotropy (μFA), fractional anisotropy (FA), and mean diffusivity (MD) were investigated to assess their sensitivities to abnormalities in TLE. μFA was significantly reduced in the ipsilateral hippocampal subfield containing the cornu ammonis 3/4 and dentate gyrus (p=0.0044), suggesting that it may be sensitive to pathological hippocampal abnormalities. Furthermore, differences between ipsilateral and contralateral μFA and MD, but not FA, correlated with ipsilateral atrophy in that same region.

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