Abstract #0467

Analysis of Hippocampal Subfield Diffusion Imaging for Lateralization in Mesial Temporal Sclerosis

Gustavo Chau Loo Kung¹, Andrew Chiu², Zachary Davey³, Nicole Mouchawar⁴, Mackenzie Carlson¹, Douglas Martin⁵, Kevin Graber³, Babak Razavi³, Jennifer McNab⁴, and Michael Zeineh⁴

¹Bioengineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford Medicine, Stanford, CA, United States, ³Neurology & Neurological Sciences, Stanford Medicine, Stanford, CA, United States, ⁴Radiology Department, Stanford University, Stanford, CA, United States, ⁵University Hospitals, 11100 Euclid Ave, OH, United States

Synopsis

We performed subfield characterization of Mesial Temporal Sclerosis (MTS) using diffusion metrics. Analysis of MRI from 57 temporal lobe epilepsy patients was based on categorization from medical records, initial clinical radiological reads, and diagnostic changes after subfield DTI analyses. We observed differences in mean diffusivity, axial diffusivity and orientation dispersion in the dentate gyrus of patients with MTS. Differences between MTS and control patients were more pronounced in left MTS.  We demonstrate how these methods may aid in the MRI identification of MTS.

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