Analysis of Hippocampal Subfield Diffusion Imaging for Lateralization in Mesial Temporal Sclerosis
Gustavo Chau Loo Kung1, Andrew Chiu2, Zachary Davey3, Nicole Mouchawar4, Mackenzie Carlson1, Douglas Martin5, Kevin Graber3, Babak Razavi3, Jennifer McNab4, and Michael Zeineh4
1Bioengineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford Medicine, Stanford, CA, United States, 3Neurology & Neurological Sciences, Stanford Medicine, Stanford, CA, United States, 4Radiology Department, Stanford University, Stanford, CA, United States, 5University Hospitals, 11100 Euclid Ave, OH, United States
We performed subfield characterization of Mesial Temporal Sclerosis (MTS) using diffusion metrics. Analysis of MRI from 57 temporal lobe epilepsy patients was based on categorization from medical records, initial clinical radiological reads, and diagnostic changes after subfield DTI analyses. We observed differences in mean diffusivity, axial diffusivity and orientation dispersion in the dentate gyrus of patients with MTS. Differences between MTS and control patients were more pronounced in left MTS. We demonstrate how these methods may aid in the MRI identification of MTS.
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