Abstract #0468

Detection of unilateral changes in thalamic volume and microstructure in focal epilepsy using 7T MRI

Benoit Testud^1,2, Roy A.M. Haast^1,2, Julia Scholly^1,2,3,4, Hugo Dary^1,2, Arnaud Le Troter^1,2, Jean-Philippe Ranjeva^1,2, Fabrice Bartolomei^3,4, and Maxime Guye^1,2

¹Aix-Marseille Université, CNRS, CRMBM, Marseille, France, ²APHM La Timone, CEMEREM, Marseille, France, ³Aix-Marseille Université, INSERM, INS, Marseille, France, ⁴Department of Epileptology, APHM La Timone, Marseille, France

Synopsis

This work evaluated differences in thalamic morphometry and T₁ across drug-resistant temporal (TLE) and non-temporal lobe epilepsy (nTLE) patients using 7T MRI. Results show bilateral thalamic atrophy across all patients, with strongest effects observed in TLE patients and ipsilateral pulvinar and mediodorsal nuclei. Moreover, T₁ appeared lower, especially in medial, lateral, and posterior nuclei. While T₁ was lowest across nTLE patients, an ipsi- vs contralateral effect was uniquely present in TLE patients. Future, joint analyses with other available myelin- and iron sensitive metrics (e.g., tissue susceptibility and diffusivity), connectivity features and clinical features will increase sensitivity to differentiate among patients.

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