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Abstract #0468

Detection of unilateral changes in thalamic volume and microstructure in focal epilepsy using 7T MRI

Benoit Testud1,2, Roy A.M. Haast1,2, Julia Scholly1,2,3,4, Hugo Dary1,2, Arnaud Le Troter1,2, Jean-Philippe Ranjeva1,2, Fabrice Bartolomei3,4, and Maxime Guye1,2
1Aix-Marseille Université, CNRS, CRMBM, Marseille, France, 2APHM La Timone, CEMEREM, Marseille, France, 3Aix-Marseille Université, INSERM, INS, Marseille, France, 4Department of Epileptology, APHM La Timone, Marseille, France


This work evaluated differences in thalamic morphometry and T1 across drug-resistant temporal (TLE) and non-temporal lobe epilepsy (nTLE) patients using 7T MRI. Results show bilateral thalamic atrophy across all patients, with strongest effects observed in TLE patients and ipsilateral pulvinar and mediodorsal nuclei. Moreover, T1 appeared lower, especially in medial, lateral, and posterior nuclei. While T1 was lowest across nTLE patients, an ipsi- vs contralateral effect was uniquely present in TLE patients. Future, joint analyses with other available myelin- and iron sensitive metrics (e.g., tissue susceptibility and diffusivity), connectivity features and clinical features will increase sensitivity to differentiate among patients.

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