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Abstract #0470

Effect of Intravoxel Incoherent Motion on NODDI Diffusion Parameters in both Healthy and Psychotic Spectrum Disorder Populations

Faye McKenna1, Veronica Yu Sui1, and Mariana Lazar1
1Radiology, New York University School of Medicine, New York, NY, United States


We investigated the intravoxel incoherent imaging (IVIM) effect on neurite orientation dispersion and density imaging (NODDI) metric calculations in both healthy controls (N=36) and a clinical population of individuals with a psychotic spectrum disorder (PSD) (N=55) by extending the original model to include a microvascular blood compartment. We found that without controlling for the IVIM effect, several NODDI metrics were possibly misestimated, which subsequently affected group comparisons and results.

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