We performed a novel 7T analysis of volumetric, microstructural and tractographic measures in the hypothalamus in MDD and matched controls. We uncovered significant differences in FA from left anterior superior and left tubular inferior, and discovered correlations between these regions and clinical measures of depression and anxiety. These findings warrant further investigations of microstructural integrity within the hypothalamus in patients with MDD and provide a basis for exploration of microstructural integrity within other neuropsychiatric disorders characterized by dysregulated mood and anxiety.
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