Abstract #0473
Tract- and Gray Matter- Based Spatial Statistics Show Microstructural Alterations in Autism Spectrum Disorder
Marissa DiPiero1,2, Hassan Cordash2,3, Molly B. Prigge4, Jace B. King4, Carolyn K. King4, Nicholas Lange5, Erin D. Bigler6,7,8,9, Brandon A. Zielinski4,6,10, Jeffrey Anderson4, Janet E. Lainhart2,11, Andrew Alexander2,11,12, and Douglas C. Dean III2,12,13
1Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, United States, 2Waisman Center, Madison, WI, United States, 3School of Computer, Data & Information Sciences, University of Wisconsin-Madison, Madison, WI, United States, 4Radiology, University of Utah, Salt Lake City, UT, United States, 5Psychiatry, Harvard School of Medicine, Boston, MA, United States, 6Neurology, University of Utah, Salt Lake City, UT, United States, 7Psychiatry, University of Utah, Salt Lake City, UT, United States, 8Psychology and Neuroscience Center, Brigham Young University, Provo, UT, United States, 9Neurology, University of California-Davis, Davis, CA, United States, 10Pediatrics, University of Utah, Salt Lake City, UT, United States, 11Psychiatry, University of Wisconsin-Madison, Madison, WI, United States, 12Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 13Pediatrics, University of Wisconsin-Madison, Madison, WI, United States
Synopsis
Advanced diffusion MRI techniques, such as Neurite Orientation Dispersion and Density Imaging (NODDI), may be used to improve characterization of gray matter (GM) and white matter (WM) microstructure of the brain. In this work, we used Gray Matter Based Spatial Statistics and Tract Based Spatial Statistics to investigate cortical GM and WM microstructural differences in individuals with autism spectrum disorder (ASD). Group differences and age by group interaction models were assessed. We demonstrate wide-spread alterations in GM and WM microstructure in ASD. Findings provide unique evidence of altered neurodevelopmental processes affecting microstructural development in ASD that persist into adulthood.
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