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Abstract #0474

Dose-dependent effects of S-ketamine on frontal neurometabolism: a 7T functional MRS study

Daphne Boucherie1, Sean van Mil1, Liesbeth Reneman1, Markus Hollmann2, and Anouk Schrantee1
1Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands, 2Department of Anaesthesiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands


The therapeutic antidepressant effect of S-ketamine has been linked to changes in glutamatergic neurotransmission. Here, we investigated the value of dynamic functional MRS compared to static MRS in detecting dose-dependent effects of subanesthetic S-ketamine on glutamate in the anterior cingulate cortex. Although significant dose-dependent subjective dissociative effects of S-ketamine were observed, we did not find significantly different glutamate changes between placebo, low-dose S-ketamine and high-dose S-ketamine, using either a “static” or “dynamic” analysis approach. Nevertheless, exploratory analyses suggest that glutamate might be modulated at specific time-points after S-ketamine administration, illustrating the potential additional information obtained from a dynamic approach.

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