Abstract #0475

Differentiation of tumor grade for renal cell carcinoma using MR Fingerprinting

Sree Harsha Tirumani^1,2, Christina J MacAskil¹, Michael Markley¹, Nicole Pritts¹, Jared C Durieux¹, Robin Elliott^3,4, Adam Calaway^5,6, Lee Ponsky^5,6, Mark Griswold¹, Chris Flask¹, and Yong Chen¹

¹Radiology, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ³Pathology, Case Western Reserve University, Cleveland, OH, United States, ⁴Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁵Urology, Case Western Reserve University, Cleveland, OH, United States, ⁶Urology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States

Synopsis

In this study, we applied kidney MR Fingerprinting in characterization of renal cell carcinoma (RCC) and correlated the quantitative T1 and T2 values with tumor grade. Our results show significantly lower T2 values between the high-grade/unclassified RCC group and the chromophobe/low-grade RCC group (55±19 vs. 90±24 msec; P<0.05), while no significant difference in T1 values was noticed (P>0.05). More importantly, MRF T1 and T2 measurements provide complementary information in characterization of RCC tumor grades with a sensitivity of 89% and a specificity of 98% in differentiation of the two RCC groups, demonstrating the strength of multi-parametric imaging.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.