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Abstract #0486

Develop CEST-detectable liposomes for nose-to-brain drug delivery

Lok Hin LAW1, Jianpan Huang1, Yang Liu1, Peng Xiao1, Ho Chi Joseph Lai1, Zilin Chen1, and Kannie W.Y. CHAN1,2,3,4
1Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, 4Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, Hong Kong


Nose-to-brain-drug-delivery is an effective route to administer drug to the brain bypassing the blood-brain-barrier(BBB). No non-invasive way to assess the delivery-efficiency available yet, especially with brain distribution. Here we investigated the imaging of nanomedicine-delivery via intranasal-administration using CEST-detectable(Iohexol loaded)mucus-penetrating-liposome(with10%PEG). The mucus-retention and penetration-efficiency was examined by in-vitro cell study and in-vivo CEST MRI after injecting the Iohexol-loaded-mucus-penetrating-liposome(Ioh-Lipo). 10%PEG-Ioh-Lipo showed a 20%higher mucus-retention than 1%PEG-Ioh-Lipo. This was also observed in-vivo with significant CEST-contrast difference in the OB between 3groups of mice at 4.3 and 3.5ppm. Moreover, liposomes were mainly found in the ONL, EPL, and MCL of the OB in histology.

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