Nose-to-brain-drug-delivery is an effective route to administer drug to the brain bypassing the blood-brain-barrier(BBB). No non-invasive way to assess the delivery-efficiency available yet, especially with brain distribution. Here we investigated the imaging of nanomedicine-delivery via intranasal-administration using CEST-detectable(Iohexol loaded)mucus-penetrating-liposome(with10%PEG). The mucus-retention and penetration-efficiency was examined by in-vitro cell study and in-vivo CEST MRI after injecting the Iohexol-loaded-mucus-penetrating-liposome(Ioh-Lipo). 10%PEG-Ioh-Lipo showed a 20%higher mucus-retention than 1%PEG-Ioh-Lipo. This was also observed in-vivo with significant CEST-contrast difference in the OB between 3groups of mice at 4.3 and 3.5ppm. Moreover, liposomes were mainly found in the ONL, EPL, and MCL of the OB in histology.
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