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Abstract #0487

MRI-based cortical shear strain measurement in healthy volunteers: repeatability study and its implications for sub-concussive trauma

Xiang Shan1, Matthew C Murphy1, Yi Sui1, Keni Zheng1, Armando Manduca2, Richard L Ehman1, John Huston III1, and Ziying Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States


Repetitive head impact (RHI) increases the risk of concussion, probably due to alterations of the brain-skull mechanical coupling. It would be of clinical value to have a reliable biomarker capable of assessing the status of the brain-skull coupling condition. MRE-based normalized octahedral shear strain (NOSS) has been proposed as a method for such brain membrane system evaluation. To verify the test-retest reliability of NOSS, datasets from 14 healthy volunteers were acquired with different vibration directions and within- and between-day scanning. This study demonstrated the excellent repeatability of the proposed method, showing the NOSS distributions were robust to loading variations.

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