HIV clade-C, found in 50% of HIV cases worldwide, has been reported to have lower neurovirulence than clade-B, more common in the global north. Numerous DTI-based studies have investigated HIV-associated microstructural damage in the brain, yet few looked at clade-C in particular. Moreover, some have reported inconsistent DTI results with respect to HIV. In this study, we use DTI and DKI to determine the extent of microstructural brain damage due to HIV clade-C infection. Our results show that a combined use of DTI and DKI can provide a better description of brain tissue damage among HIV clade-C infected individuals.