Abstract #0489

Estimating Cerebrovascular Compliance from Normocapnia and Hypercapnia BOLD Pulsatility Mapping

Jake Valsamis¹, Nicholas Luciw¹, Walter Swardfager^2,3, Andrew Lim^2,4, Joel Ramirez², Sandra Black^2,4, and Bradley J MacIntosh^1,5

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Evaluative Clinical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada, ⁴Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁵Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Synopsis

Measuring intracranial vascular compliance (VC) may help characterize a patient’s resilience to Alzheimer’s disease and dementia. In this study, we estimate VC from a BOLD MRI cerebrovascular reactivity (CVR) protocol by measuring cardiac-related BOLD pulsatility and end-tidal CO₂ during periods of hypercapnia and normocapnia. We measured high VC in regions proximal to major cerebral arteries like the thalamus and insula, and low VC in the parietal lobe. This study demonstrates the feasibility of extracting additional information from BOLD-CVR experiments and suggests regional differences in VC. Future work will include a second cohort to estimate VC in different patient populations.

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