Estimating Cerebrovascular Compliance from Normocapnia and Hypercapnia BOLD Pulsatility Mapping
Jake Valsamis1, Nicholas Luciw1, Walter Swardfager2,3, Andrew Lim2,4, Joel Ramirez2, Sandra Black2,4, and Bradley J MacIntosh1,5
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Evaluative Clinical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada, 4Department of Medicine, University of Toronto, Toronto, ON, Canada, 5Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Measuring intracranial vascular compliance (VC) may help characterize a patient’s resilience to Alzheimer’s disease and dementia. In this study, we estimate VC from a BOLD MRI cerebrovascular reactivity (CVR) protocol by measuring cardiac-related BOLD pulsatility and end-tidal CO2 during periods of hypercapnia and normocapnia. We measured high VC in regions proximal to major cerebral arteries like the thalamus and insula, and low VC in the parietal lobe. This study demonstrates the feasibility of extracting additional information from BOLD-CVR experiments and suggests regional differences in VC. Future work will include a second cohort to estimate VC in different patient populations.
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