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Abstract #0493

Inter- & Intra-visit Reproducibility of Free-Breathing Magnetic Resonance Imaging in Pediatric Cystic Fibrosis Lung Disease

Samal Munidasa1,2, Brandon Zanette1, Marcus Couch1,2,3, Robert Grimm4, Ravi Seethamraju5, Marie-Pier Dumas6, Wallace Wee6, Jacky Au6, Sharon Braganza1, Daniel Li1, Felix Ratjen1,6, and Giles Santyr1,2
1Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Siemens Healthcare Limited, Montreal, QC, Canada, 4MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 5MR Collaborations North East, Siemens Healthineers, North East, NY, United States, 6Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada


Free-breathing lung MRI has been shown to be a responsive measure to CF pulmonary exacerbations treatments but have not been used to track stable disease progression longitudinally. In this study we determined the intra- and inter-scan reproducibility of free-breathing lung MRI in healthy and stable pediatric CF across 2 visits and compared to hyperpolarized Xenon MRI (Xe-MRI). Xe-MRI and free-breathing lung show a high intra-scan reproducibility in stable CF subjects, but free-breathing lung MRI showed a low inter-scan reproducibility. However, free-breathing lung MRI significantly correlated with Xe-MRI suggesting that it may be an alternative to expensive, and less wide-spread Xe-MRI.

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