Assessment of Lung Ventilation and Perfusion of Premature Infants at 1.5 Tesla Using Phase-Resolved Functional Lung (PREFUL) MRI in the NICU
Jonathan P Dyke1, Andreas Voskrebenzev2,3, Lauren P Blatt4, Jens Vogel-Claussen2, Robert Grimm5, Jeffrey P Perlman4, and Arzu Kovanlikaya1
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 3Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 4Pediatrics, Weill Cornell Medicine, New York, NY, United States, 5Siemens Healthineers, Erlangen, Germany
The purpose of this study was to evaluate quantitative measures of lung function in premature newborns using (PREFUL) MRI on a 1.5 Tesla scanner located within the neonatal intensive care unit (NICU). MRI can non-invasively assess ventilation and perfusion defects in the infant lung without sedation, ionizing radiation or contrast administration. We performed (PREFUL) MRI in 6 neonates [5 preterm/1 term] without respiratory distress to assess lung function in this normal population. Continuation of this work may allow clinicians to quantitatively assess response to treatment in this vulnerable population with respiratory distress.
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