Abstract #0494

Assessment of Lung Ventilation and Perfusion of Premature Infants at 1.5 Tesla Using Phase-Resolved Functional Lung (PREFUL) MRI in the NICU

Jonathan P Dyke¹, Andreas Voskrebenzev^2,3, Lauren P Blatt⁴, Jens Vogel-Claussen², Robert Grimm⁵, Jeffrey P Perlman⁴, and Arzu Kovanlikaya¹

¹Radiology, Weill Cornell Medicine, New York, NY, United States, ²Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ³Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ⁴Pediatrics, Weill Cornell Medicine, New York, NY, United States, ⁵Siemens Healthineers, Erlangen, Germany

Synopsis

The purpose of this study was to evaluate quantitative measures of lung function in premature newborns using (PREFUL) MRI on a 1.5 Tesla scanner located within the neonatal intensive care unit (NICU). MRI can non-invasively assess ventilation and perfusion defects in the infant lung without sedation, ionizing radiation or contrast administration. We performed (PREFUL) MRI in 6 neonates [5 preterm/1 term] without respiratory distress to assess lung function in this normal population. Continuation of this work may allow clinicians to quantitatively assess response to treatment in this vulnerable population with respiratory distress.

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