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Abstract #0513

Gray matter microstructure imaging by b-tensor encoding at high b-values and high spatial resolution

Geraline Vis1, Nicola Spotorno2, Björn Lampinen1, Filip Szczepankiewicz1, and Markus Nilsson1
1Department of Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden, 2Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden


Studying gray matter microstructure with dMRI is challenging because of partial volume effects and high orientation dispersion. In this work, we propose a novel method that combines spherical b-tensor encoding, strong diffusion weighting and super-resolution reconstruction to perform high-resolution microstructure imaging of gray matter. We map the tissue mean diffusivity and the microscopic anisotropy which, by their design, are unaffected by partial volume effects and intra-voxel orientation dispersion. We demonstrate the approach in human brain in vivo at a resolution of 1.4 mm isotropic.

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