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Abstract #0514

Fast acquisitions for mean kurtosis and microscopic fractional anisotropy

Santiago Coelho1, Filip Szczepankiewicz2, Els Fieremans1, and Dmitry S. Novikov1
1Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University, School of Medicine, New York, NY, United States, 2Department of Diagnostic Radiology, Clinical Sciences, Lund University, Lund, Sweden


We propose two acquisition protocols that minimize the number of directions needed for estimating MD, FA, MK, and $$$\mu$$$FA. Using symmetric trace-free decompositions of the diffusion, kurtosis, and covariance tensors, we design acquisitions that cancel unnecessary tensor elements, thereby reducing the number of directions needed to generate the maps. Our protocols consist of $$$3b_1+6b_2=9$$$ DWIs for MD+MK in a 1-minute scan, and $$$6b_1^\text{LTE}+6b_2^\text{LTE}+3b_{1.5}^\text{STE}=15$$$ DWIs for MD+FA+MK+$$$\mu$$$FA in a 2-minute scan. We show the feasibility of these approaches on a healthy volunteer.

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