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Abstract #0515

Correlation Tensor MRI reveals dynamic changes in diffusion kurtosis sources along stroke progression

Rita Alves1, Rafael Neto Henriques1, Sune Nørhøj Jespersen2,3, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3Department of Physics and Astronomy, Aarhus University, Aarhus, Portugal


Correlation Tensor Imaging is emerging as a novel methodology for resolving diffusional kurtosis sources. Here, we decouple the anisotropic (Kaniso), isotropic (Kiso), and microscopic kurtosis (μK) sources and map them along the progression of experimental ischemia. Our results indicate that μK and Kaniso, associated with cross sectional variance (tentatively associated with neurite beading) and Kiso, likely reflecting edema formation, are pivotal markers for pathology. Our findings are promising for more specific characterizations of stroke lesions and a better understanding of tissue injury.

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