Correlation Tensor Imaging is emerging as a novel methodology for resolving diffusional kurtosis sources. Here, we decouple the anisotropic (Kaniso), isotropic (Kiso), and microscopic kurtosis (μK) sources and map them along the progression of experimental ischemia. Our results indicate that μK and Kaniso, associated with cross sectional variance (tentatively associated with neurite beading) and Kiso, likely reflecting edema formation, are pivotal markers for pathology. Our findings are promising for more specific characterizations of stroke lesions and a better understanding of tissue injury.
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