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Abstract #0516

Oscillating Gradient (OGSE) and Microscopic Anisotropy Diffusion in the in vivo and ex vivo Marmoset Brain

Tales Santini1, Naila Rahman1, Alyson Shim1, Wataru Inoue1, Stefan Everling1, and Corey Baron1
1Western University, London, ON, Canada

Synopsis

We investigated OGSE and μFA diffusion techniques for the first time in the common marmoset (Callithrix jacchus) brain, which revealed comparable values to those found in humans. The same animal was scanned in vivo and after fixation of the brain, allowing comparison of in vivo and ex vivo OGSE and μFA parameters for the first time in marmosets. There were differences in kurtosis, μFA, and μA that may be caused by slight neurite beading and tissue shrinkage during perfusion/fixation, and temperature differences.

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Keywords