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Abstract #0518

Short superficial U-fiber systems and aging: a longitudinal diffusion MRI study

Kurt G Schilling1, Derek Archer2, Fang-Cheng Yeh3, Francois Rheault2, Leon Y Cai2, Timothy Hohman2, Andrea T Shafer4, Susan M Resnick4, Angela Jefferson2, Adam W Anderson2, Hakmook Kang2, and Bennett A Landman2
1Vanderbilt University Medical Center, Nashville, TN, United States, 2Vanderbilt University, Nashville, TN, United States, 3University of Pittsburgh Medical Center, Pittsburg, PA, United States, 4National Institute on Aging, Baltimore, MD, United States


Superficial U-fiber systems are understudied using diffusion tractography, despite making up a majority of the white matter connections. Here, we used a large, longitudinal dataset from the Baltimore Longitudinal Study of Aging, in combination with innovations in U-fiber tractography dissection, to study U-fiber systems in an aging population. We characterize microstructural features, and for the first time, macrostructural features of length and volume, and find significant associations with age. Characterizing what changes occur, and where they occur, in U-fiber systems will complement traditional long-range tractography research to better understand the biological mechanisms of normal aging.

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