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Abstract #0522

First templates of human brain kurtosis sources: relevance of microscopic kurtosis from Correlation Tensor MRI at 3 Tesla

Lisa Novello1, Rafael Neto Henriques2, Andrada Ianuş2, Thorsten Feiweier3, Noam Shemesh2, and Jorge Jovicich1,4
1Center for Mind/Brain Sciences - CIMeC, University of Trento, Rovereto (Trento), Italy, 2Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Center for Medical Sciences - CISMeD, University of Trento, Rovereto (Trento), Italy


The Correlation Tensor MRI (CTI) framework has been recently formulated to disentangle anisotropic, isotropic, and microscopic kurtosis sources without a priori assumptions from Double-Diffusion-Encoding (DDE) data. In this work, group average maps (templates) are presented for the first time, thereby mapping the contrasts for anisotropic and isotropic kurtosis, and non-vanishing positive microscopic kurtosis in grey and white matter. The relative weight of the microscopic kurtosis within the total kurtosis, and the bias associated with neglecting this component under the Multiple Gaussian Component assumption are investigated and suggest that this component significantly contributes to the total diffusional kurtosis.

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