Validation of diffusion MRI-derived white matter microstructure metrics using 3D electron microscopy in injured rat brain
Ricardo Coronado-Leija1, Ali Abdollahzadeh2, Hong-Hsi Lee3, Santiago Coelho1, Raimo A Salo2, Jussi Tohka2, Alejandra Sierra2, Dmitry S Novikov1, and Els Fieremans1
1Radiology, New York University School of Medicine, New York, NY, United States, 2University of Eastern Finland, Kuopio, Finland, 3Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
To validate the standard model of diffusion in white matter, we characterized injured rat brain microstructure using 3D EM and ex-vivo MRI. Using histology, we demonstrated that the rotational invariants $$$p_l$$$ of the fiber orientation distribution follow a power-law and that the axon diameter histogram is described well by a generalized extreme value distribution. Comparing 3D EM and dMRI, we found that the SM parameters correlate specifically with their histology counterpart, and revealed the specificity of the intra-axonal diffusivity to axonal beading in traumatic brain injury.
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