To validate the standard model of diffusion in white matter, we characterized injured rat brain microstructure using 3D EM and ex-vivo MRI. Using histology, we demonstrated that the rotational invariants $$$p_l$$$ of the fiber orientation distribution follow a power-law and that the axon diameter histogram is described well by a generalized extreme value distribution. Comparing 3D EM and dMRI, we found that the SM parameters correlate specifically with their histology counterpart, and revealed the specificity of the intra-axonal diffusivity to axonal beading in traumatic brain injury.
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