Longitudinal associations between blood biomarkers and white-matter MRI in sport-related concussion: A study of the NCAA-DoD CARE Consortium
Yu-Chien Wu1, Qiuting Wen2, Jessica Gill3, Rhea Thukral4, Sujuan Gao5, Kathleen Lane5, Timothy Meier6, Larry Riggen5, Jaroslaw Harezlak7, Christopher Giza8, Joshua Goldman9, Kevin Guskiewicz10, Jason Mihalik 10, Stephen LaConte11, Stefan Duma12, Steven Broglio13, Andrew Saykin2, Thomas McAllister14, and Michael McCrea6
1Department of Radiology and Imaging Sciences, Department of RadioIndiana University School of Medicine, Indianapolis, IN, United States, 2Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 3National Institute of Health, Bethesda, MD, United States, 4Department of Radiology, Indiana School of Medicine, Indianapolis, IN, United States, 5Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, United States, 6Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 7Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, IN, United States, 8Department of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, United States, 9Family Medicine, Ronald Reagan UCLA Medical Center, UCLA Health - Santa Monica Medical Center, Los Angeles, CA, United States, 10Department of Exercise and Sport Science, Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center, Chapel Hill, NC, United States, 11School of Biomedical Engineering and Sciences, Wake-Forest and Virginia Tech University, Roanoke, VA, United States, 12School of Biomedical Engineering and Sciences, Wake-Forest and Virginia Tech University, Blacksburg, VA, United States, 13NeuroTrauma Research Laboratory, Michigan Concussion Center, University of Michigan, Ann Arbor, MI, United States, 14Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States
White matter structural changes occur when an athlete experiences a concussion. To determine if serum biomarkers are a good concussion diagnosis, it seems prudent to associate white matter structural changes to longitudinal biomarker samples. Longitudinal blood biomarkers and DTI scanning from 77 collegiate athletes were collected across 3 timepoints and tested for associations. Tau was found to have the most significant associations. It was concluded that tau is the most sensitive for white-matter micro-structures.
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